Nerve growth factor

Story Tools Send to a friend Printer friendly page Get PDF

RELATED LINKS

Objective This study was designed to evaluate the level of nerve growth factor (NGF) and transforming growth factor - β2 (TGF- β2) in IDDM to evaluate their role in pathogenesis of IDDM, where both previous cytokines have an immunological effects. Elevated levels of' NGF has been reported in certain autoimmune diseases as rheumatoid arthritis , systemic lupus erythromatosus, allergic diseases and bronchial asthma. whereas TGF- β2 is an immunosuppressor which is known to play a role in regulating cell proliferation. The role of this cytokines has been proposed in the pathogenesis of insulin dependant diabetes mellitus (IDDM), some clinical studies have yet measured its serum level in these disease to evaluate there roles in pathogeneses of NIDDM&IDDM . Material &Methods: our study was done on diabetic patients regularly visit pediatric out clinic of diabetes in EL-Minia university hospital . NGF and TGF- β2 levels were measured in the serum of the patients with IDDM (n == 20) and values were compared to those of age-matched normal subjects (n = 13). All IDDM patients were on multiple daily insulin injections and on no other medications. Both NGF and TGF-β2 were measured by a solid-phase sandwich, two-site, enzyme-linked immunoassay (ELISA).Results: Serum NGF levels were significantly elevated in IDDM patients (1798 ±296 pg/ml) compared to those of age-matched control (687±145pg/ml); (p < .001) .Serum TGF- β2 levels were significantly decrease in IDDM patient (294± 48pg/ml) when compared with the healthy control (577 ± 74pg/ml); (p < .001). There was no correlation between the levels of NGF and TGF- β2. Conclusion: We concluded that an increase in NGF and a decrease in TGF- β2 levels are present in patients with insulin dependant diabetes mellitus and that both cytokines may play independent roles in the pathogenesis of this disease.
Key Words: NGF (nerve growth factor); TGF-β2(Transforming growth factor-β2) &IDDM(Insulin dependant Diabetes mellitus ).
author: Samir Tamer Abdallah1 ,Ibrahim Mohammad Marey1, Essmat AbdElaziz Elsharkawi2

address:
Dr samir Tamer Abdullah ,departement of pediatrics Al-MINYA university hospital, AL-MINYA, EGYPT.